Understanding how microRNA changes affect Fragile X Syndrome
Official title: Mechanisms of microRNA dysregulation in Fragile X Syndrome
Funded at Emory University · NIH-10934352 · Data updated 2026-11-12
This study is looking at how tiny molecules called microRNAs are involved in Fragile X Syndrome, a condition that affects learning and behavior, to help find new ways to improve the lives of those who have it.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 13, 2023 |
| Project end | September 12, 2026 |
| Funding year | 2024 |
| Award (this year) | $76,756 |
| NIH project number | 5F32MH135636-02 |
| Project ID | NIH-10934352 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Fragile X Syndrome or those who are carriers of the FMR1 gene mutation.
✕Less likely to help
Patients without a diagnosis of Fragile X Syndrome or those not affected by FMR1 gene mutations may not benefit from this research.
What this research studies
This research investigates the role of microRNAs in Fragile X Syndrome (FXS), a condition that leads to intellectual disabilities and autism. By examining how the loss of a specific protein, FMRP, disrupts the regulation of gene expression, the study aims to uncover the underlying mechanisms that contribute to the symptoms of FXS. The approach involves analyzing human models of FXS to identify changes in the microRNA landscape and their impact on neuronal processes. This research could provide insights into potential therapeutic targets for improving outcomes in affected individuals.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive and behavioral outcomes for individuals with Fragile X Syndrome.
How similar studies have gone: While there have been studies on microRNA dysregulation in various conditions, this research aims to provide a novel and comprehensive characterization specifically in human models of Fragile X Syndrome.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Kosti, Adam — Emory University
- Study coordinator: Kosti, Adam
Related research
Other NIH-funded projects on the same topics.
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Understanding Fragile X Syndrome: How it progresses and affects daily life
A long-term study using existing Fragile X data to map how the condition changes over time in children and young adults, including how autism, race, and location influence outcomes.
-
Sleep and mood links in Fragile X Syndrome
A short, patient-friendly study to understand how sleep problems relate to mood and depressive symptoms in people with Fragile X–linked autism.
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Connecting 3D genome misfolding to gene silencing in Fragile X syndrome
A study in people with Fragile X syndrome focuses on how 3D genome folding errors may turn off important genes, contributing to the condition’s features.
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Cortical circuit problems in Fragile X mice and people
Researchers are studying how brain circuits go awry in Fragile X syndrome by comparing mice and people to understand why certain brain rhythms and responses are altered.
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Brain biology in fragile X syndrome: how brain signals unfold and vary in patients
This grant supports research to understand brain signals and why symptoms vary in people with fragile X syndrome, aiming to translate findings into better care.
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Brain research on Fragile X Syndrome to improve therapies
A multi-year program studies brain function and differences in Fragile X Syndrome to help develop better treatments for people with FXS.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.