Understanding how microRNA changes affect Fragile X Syndrome
Mechanisms of microRNA dysregulation in Fragile X Syndrome
This study is looking at how tiny molecules called microRNAs are involved in Fragile X Syndrome, a condition that affects learning and behavior, to help find new ways to improve the lives of those who have it.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10934352 on NIH RePORTER |
What this research studies
This research investigates the role of microRNAs in Fragile X Syndrome (FXS), a condition that leads to intellectual disabilities and autism. By examining how the loss of a specific protein, FMRP, disrupts the regulation of gene expression, the study aims to uncover the underlying mechanisms that contribute to the symptoms of FXS. The approach involves analyzing human models of FXS to identify changes in the microRNA landscape and their impact on neuronal processes. This research could provide insights into potential therapeutic targets for improving outcomes in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Fragile X Syndrome or those who are carriers of the FMR1 gene mutation.
Not a fit: Patients without a diagnosis of Fragile X Syndrome or those not affected by FMR1 gene mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve cognitive and behavioral outcomes for individuals with Fragile X Syndrome.
How similar studies have performed: While there have been studies on microRNA dysregulation in various conditions, this research aims to provide a novel and comprehensive characterization specifically in human models of Fragile X Syndrome.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Kosti, Adam — Emory University
- Study coordinator: Kosti, Adam
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.