Understanding how microRNA affects mitochondria in the brain
Characterizing the regulatory roles of microRNA on mitochondria in the mammalian CNS
This study is looking at how tiny molecules called microRNA affect the energy production in brain cells, especially in conditions like Fragile X Syndrome, to help us understand more about how these processes might contribute to neuropsychiatric disorders.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11068124 on NIH RePORTER |
What this research studies
This research investigates the role of microRNA in regulating mitochondrial function within the central nervous system, particularly in relation to neuropsychiatric disorders like Fragile X Syndrome. By utilizing advanced techniques to analyze the interactions between microRNA and mitochondrial RNA, the study aims to uncover how these interactions contribute to mitochondrial health and energy production in neurons. The research will focus on identifying specific cell types and subcellular locations where these interactions occur, which could provide insights into the underlying mechanisms of related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Fragile X Syndrome or other neurodevelopmental disorders that may involve mitochondrial dysfunction.
Not a fit: Patients with neuropsychiatric disorders not related to mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neuropsychiatric disorders by improving mitochondrial function in affected patients.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial dysfunction in neuropsychiatric disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Eiss, Emily — Johns Hopkins University
- Study coordinator: Eiss, Emily
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.