Understanding how microRNA affects mitochondria in the brain
Official title: Characterizing the regulatory roles of microRNA on mitochondria in the mammalian CNS
Funded at Johns Hopkins University · NIH-11068124 · Data updated 2026-11-12
This study is looking at how tiny molecules called microRNA affect the energy production in brain cells, especially in conditions like Fragile X Syndrome, to help us understand more about how these processes might contribute to neuropsychiatric disorders.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 5, 2024 |
| Project end | September 4, 2027 |
| Funding year | 2024 |
| Award (this year) | $51,974 |
| NIH project number | 1F31MH136717-01A1 |
| Project ID | NIH-11068124 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Fragile X Syndrome or other neurodevelopmental disorders that may involve mitochondrial dysfunction.
✕Less likely to help
Patients with neuropsychiatric disorders not related to mitochondrial dysfunction may not benefit from this research.
What this research studies
This research investigates the role of microRNA in regulating mitochondrial function within the central nervous system, particularly in relation to neuropsychiatric disorders like Fragile X Syndrome. By utilizing advanced techniques to analyze the interactions between microRNA and mitochondrial RNA, the study aims to uncover how these interactions contribute to mitochondrial health and energy production in neurons. The research will focus on identifying specific cell types and subcellular locations where these interactions occur, which could provide insights into the underlying mechanisms of related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neuropsychiatric disorders by improving mitochondrial function in affected patients.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial dysfunction in neuropsychiatric disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Eiss, Emily — Johns Hopkins University
- Study coordinator: Eiss, Emily
Related research
Other NIH-funded projects on the same topics.
-
Targeting hidden brain injuries in iTTP to improve long-term brain health
A researcher aims to find out how silent brain injuries in people with immune thrombotic thrombocytopenic purpura (iTTP) happen, how they affect thinking and stroke risk, and how to prevent them.
-
Accelerated flap coverage for severe leg injuries: earlier reconstruction vs standard timing
This study tests whether doing early flap coverage after a severe leg injury lowers infection risk and improves healing for patients with open wounds and bone injury.
-
Placebo-controlled shunting for iNPH: does the surgery help with walking and balance?
A doctor-led trial at Johns Hopkins will test whether a shunt surgery improves walking and balance in older adults with idiopathic normal pressure hydrocephalus.
-
Omalizumab for COPD patients with allergen sensitization and exposure
A multicenter trial will test whether adding omalizumab helps people with COPD who are allergic to common indoor allergens and are exposed to them.
-
Johns Hopkins Total Worker Health Center focusing on mental health
A nationwide center at Johns Hopkins is working to improve mental health and well-being among workers by studying workplace health strategies and translating findings into practical tools.
-
Role of fat droplets in liver fat and inflammatory signals in NAFLD
A study at Johns Hopkins will explore how fat droplets in the liver influence molecules that drive inflammation and progression of non-alcoholic fatty liver disease (NAFLD) in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.