Understanding how microRNA-320 affects skeletal muscle health
Official title: Investigation of the Functional Roles of MicroRNA-320 in Skeletal Muscle
Funded at Stanford University · NIH-10811546 · Data updated 2026-11-12
This study is looking at how a tiny molecule called microRNA-320 affects muscle health, especially when muscles weaken from not being used or from nerve damage, and it’s for anyone interested in understanding and improving muscle strength and recovery.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 25, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $374,204 |
| NIH project number | 1R21AR082627-01A1 |
| Project ID | NIH-10811546 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing muscle atrophy or weakness due to disuse, denervation, or related diseases.
✕Less likely to help
Patients with muscle conditions unrelated to microRNA-320 or those not experiencing muscle atrophy may not benefit from this research.
What this research studies
This research investigates the role of microRNA-320 in skeletal muscle, particularly how its reduction contributes to muscle atrophy and weakness due to disuse and denervation. By using a specialized mouse model that lacks this microRNA, researchers aim to uncover the mechanisms behind muscle degradation and explore potential therapeutic approaches. The study will involve detailed phenotypic characterization of these mice and preliminary treatment trials to assess the impact of restoring microRNA-320 levels on muscle health.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for muscle-related diseases and conditions that cause muscle weakness.
How similar studies have gone: Previous research has shown promising results in understanding the role of microRNAs in muscle health, suggesting that this approach could yield significant insights.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Shrager, Joseph B — Stanford University
- Study coordinator: Shrager, Joseph B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.