Understanding how microglial cells affect neuron health as we age
Microglial lysosomes and selective neuronal vulnerability
This study is looking at how brain immune cells help keep the connections between nerve cells healthy as we get older, especially to understand why some nerve cells are more likely to get damaged, which can affect our thinking and memory; the goal is to find ways to support brain health in older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11041025 on NIH RePORTER |
What this research studies
This research investigates the role of microglial cells, which are immune cells in the brain, in maintaining the health of synapses, the connections between neurons. It aims to uncover why certain neurons are more susceptible to damage and loss as we age, particularly in relation to cognitive decline and neurodegenerative diseases. By studying the changes in microglial behavior and their impact on synapses over time, the research seeks to identify potential therapeutic targets for improving neuronal health in aging populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing cognitive decline or those at risk for neurodegenerative diseases.
Not a fit: Patients who are not experiencing age-related cognitive issues or neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cognitive decline and neurodegenerative diseases in older adults.
How similar studies have performed: Previous research has shown promising results in understanding the role of microglia in neurodegenerative diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: De Biase, Lindsay Mitchell — University of California Los Angeles
- Study coordinator: De Biase, Lindsay Mitchell
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.