Understanding how microglia regulate progranulin levels in the brain
Microglial regulation of Progranulin levels
This study is looking at how certain brain cells help control a protein called progranulin, which is important for brain health and linked to diseases like Alzheimer's, to find new ways to treat or prevent these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10765631 on NIH RePORTER |
What this research studies
This research investigates the role of microglia, a type of immune cell in the brain, in regulating levels of progranulin, a protein linked to various neurological disorders. The study focuses on genetic mutations that affect progranulin levels and their connection to conditions like Alzheimer's disease and frontotemporal lobar degeneration. By exploring the cellular mechanisms involved, the research aims to identify potential therapeutic targets that could help restore normal progranulin levels and improve brain health. Patients may benefit from insights gained into how these processes can be manipulated to treat or prevent neurodegenerative diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with genetic mutations affecting progranulin levels or those diagnosed with Alzheimer's disease or frontotemporal lobar degeneration.
Not a fit: Patients with neurodegenerative diseases not associated with progranulin levels or those without genetic mutations affecting this protein may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve outcomes for patients with neurodegenerative diseases linked to progranulin deficiency.
How similar studies have performed: Previous research has shown promising results in understanding the role of progranulin in neurodegenerative diseases, indicating that this approach has potential for success.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Lim, Janghoo — Yale University
- Study coordinator: Lim, Janghoo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.