Understanding how microglia contribute to brain health and inflammation
Transcriptional Control of Microglia Diversification and Inflammation
This study is looking at how brain immune cells called microglia help keep our brains healthy and how they might contribute to diseases like Alzheimer's, with the goal of finding new ways to treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10810676 on NIH RePORTER |
What this research studies
This research investigates the role of microglia, the immune cells of the brain, in maintaining brain health and their involvement in neurodegenerative diseases. The study focuses on how specific genetic mechanisms influence the behavior of microglia in different brain regions, particularly in response to inflammation and neuronal damage. By examining the effects of certain proteins that regulate gene expression, researchers aim to uncover how microglia can either protect or harm neurons. This research could lead to new insights into treating conditions like Alzheimer's disease and other neurodegenerative disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing neurodegenerative conditions or those at risk for such diseases.
Not a fit: Patients with acute neurological injuries or those not affected by neurodegenerative diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for neurodegenerative diseases by targeting microglial function.
How similar studies have performed: Previous research has shown promising results in understanding microglial function and its implications for neurodegeneration, indicating that this approach has potential for significant breakthroughs.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Schaefer, Anne — Icahn School of Medicine at Mount Sinai
- Study coordinator: Schaefer, Anne
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.