Understanding how microglia can be targeted to treat glioblastoma
Mechanism and therapeutic potential of microglia regulation in glioblastoma
This study is looking at how certain immune cells in the brain, called microglia, affect the growth of glioblastoma, a tough type of brain cancer, to help find better treatments for patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-11126347 on NIH RePORTER |
What this research studies
This research investigates the role of microglia, a type of immune cell in the brain, in glioblastoma, the most aggressive form of brain cancer. The study aims to understand how microglia contribute to tumor growth and immune suppression, which could lead to new treatment strategies. Researchers will explore the molecular mechanisms that drive microglial infiltration into tumors and how this affects the effectiveness of immunotherapy. By targeting these processes, the research seeks to improve outcomes for patients with glioblastoma.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with glioblastoma who are seeking innovative treatment options.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the immune response against glioblastoma, potentially improving survival rates.
How similar studies have performed: Previous research has shown promise in targeting the tumor microenvironment in various cancers, suggesting that this approach could be beneficial for glioblastoma as well.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Chen, Peiwen — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Chen, Peiwen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.