Understanding how microglia affect injured motoneurons
Microglial Activity on Injured Motoneurons
This study is looking at how brain immune cells called microglia help or hurt nerve cells after injuries, which could lead to new treatments for conditions like ALS.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10994059 on NIH RePORTER |
What this research studies
This research investigates the role of microglia, a type of immune cell in the brain and spinal cord, in the health and survival of motoneurons after peripheral nerve injuries. By using advanced microscopy techniques, the study aims to visualize how microglia interact with injured motoneurons and to identify the signaling mechanisms that influence whether these neurons recover or die. The goal is to uncover the dynamics of microglial behavior and their communication with motoneurons, which could lead to new therapeutic strategies for conditions like amyotrophic lateral sclerosis (ALS).
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced peripheral nerve injuries or are affected by motoneuron diseases such as ALS.
Not a fit: Patients with non-neurological conditions or those who have not experienced nerve injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with motoneuron diseases, enhancing recovery and functional outcomes.
How similar studies have performed: Previous research has shown promising results in understanding microglial roles in neurodegeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Pottorf, Tana — Emory University
- Study coordinator: Pottorf, Tana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.