Understanding how mice produce vocal sounds while breathing
Determination of the motor patterning system for murine vocalizations with breathing
This study looks at how baby mice make sounds while breathing, hoping to understand the brain connections that help control these vocalizations, which might also give us clues about how communication works in humans and other animals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11049173 on NIH RePORTER |
What this research studies
This research investigates the neural mechanisms behind vocalizations in mice, focusing on how these sounds are produced in coordination with breathing. By studying the brainstem circuits that control both vocalization and respiration, the researchers aim to identify a central pattern generator (CPG) that governs the rhythmic structure of these sounds. The study uses neonatal murine cries, which are similar to human infant cries, to explore the underlying neural connections and patterns. This could provide insights into the fundamental aspects of vocal communication across species.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with communication disorders, particularly those on the autism spectrum.
Not a fit: Patients who do not have communication disorders or related conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of vocal communication disorders and lead to new therapeutic approaches for conditions like autism.
How similar studies have performed: While the investigation of vocalization patterns is a well-explored area, the specific focus on a central pattern generator for vocalizations in mice is a novel approach.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Yackle, Kevin — University of California, San Francisco
- Study coordinator: Yackle, Kevin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.