Understanding how methylphenidate affects the brain in PTSD patients
Official title: Computational Analysis of Neural Effects of Methylphenidate in Posttraumatic Stress Disorder
Funded at VA San Diego Healthcare System · NIH-11115539 · Data updated 2026-11-12
This study is looking at how the ADHD medication methylphenidate affects veterans with PTSD, using brain scans and behavior tests to help find better treatment options for those struggling with PTSD symptoms.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | VA San Diego Healthcare System NIH-funded |
| Lab location | 1 site (San Diego, United States) |
| Project start | July 1, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| NIH project number | 5IK2CX001887-06 |
| Project ID | NIH-11115539 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans diagnosed with posttraumatic stress disorder who may benefit from pharmacological interventions.
✕Less likely to help
Patients who do not have PTSD or those who are not veterans may not receive any benefit from this research.
What this research studies
This research investigates the effects of methylphenidate, a medication commonly used to treat ADHD, on individuals with posttraumatic stress disorder (PTSD). By combining computational analysis, pharmacological treatment, and brain imaging techniques, the study aims to uncover how this medication influences complex behaviors associated with PTSD. The goal is to better understand the underlying neural mechanisms of PTSD symptoms and improve treatment options for affected veterans. Participants may undergo assessments that include behavioral evaluations and brain scans to gather comprehensive data.
Why it matters
Potential benefit: If successful, this research could lead to more effective, targeted treatments for veterans suffering from PTSD.
How similar studies have gone: Previous studies have shown promising results with similar pharmacological approaches in treating PTSD, indicating potential for success in this research.
Where this research is happening
-
VA San Diego Healthcare System
San Diego, United States Active
Researchers
- Principal investigator: Howlett, Jonathon R — VA San Diego Healthcare System
- Study coordinator: Howlett, Jonathon R
Related research
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-
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-
Understanding how sensing sounds and sights affect PTSD
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.