Understanding how methionine metabolism affects health and disease
Deciphering the crosstalk between methionine metabolism and methyltransferases in health and disease
This study is looking at how the way our bodies use a nutrient called methionine affects important functions like making proteins and protecting our cells, with the hope of finding new treatments for diseases that could help patients feel better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10890710 on NIH RePORTER |
What this research studies
This research investigates the role of methionine metabolism in regulating critical cellular functions such as protein synthesis and antioxidant defense. By exploring how changes in methionine levels influence various diseases, the study aims to identify specific methyltransferases that mediate these effects. The approach involves detailed biochemical analyses to uncover the molecular mechanisms linking methionine availability to cellular processes. Patients may benefit from insights that could lead to new therapeutic strategies targeting these metabolic pathways.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to metabolic dysregulation, such as certain cancers or age-related disorders.
Not a fit: Patients with stable metabolic conditions that do not involve methionine metabolism may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments for diseases linked to methionine metabolism imbalances.
How similar studies have performed: Previous research has shown promising results in understanding metabolic pathways, suggesting potential for success in this area as well.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Parkhitko, Andrey a — University of Pittsburgh at Pittsburgh
- Study coordinator: Parkhitko, Andrey a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.