Understanding how methamphetamine craving develops over time
Molecular mechanisms of incubation of methamphetamine craving
This study is looking at why people might crave methamphetamine more after they've stopped using it for a while, using rats to explore how certain brain cells are involved in those cravings, which could help us understand and prevent relapses.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project ID | NIH-11311745 on NIH RePORTER |
What this research studies
This research investigates the biological mechanisms that lead to increased craving for methamphetamine, particularly after periods of abstinence. Using a model involving rats, the study focuses on specific neurons in the brain that are involved in drug-seeking behavior. By employing advanced techniques like optogenetics and electrophysiology, the researchers aim to differentiate the roles of various types of neurons in the craving process. This could provide insights into how cravings intensify and potentially lead to relapse.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of methamphetamine use who are currently in recovery or abstinence.
Not a fit: Patients who have never used methamphetamine or those with other substance use disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing relapse in individuals recovering from methamphetamine addiction.
How similar studies have performed: Previous research has shown promising results in understanding drug cravings through similar biological approaches, indicating potential for success in this area.
Where this research is happening
College Station, United States
- Texas A&m University — College Station, United States (Active)
Researchers
- Principal investigator: Swinford-Jackson, Sarah E. — Texas A&m University
- Study coordinator: Swinford-Jackson, Sarah E.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.