Understanding how methamphetamine craving develops over time
Official title: Molecular mechanisms of incubation of methamphetamine craving
Funded at Texas A&m University · NIH-11311745 · Data updated 2026-11-12
This study is looking at why people might crave methamphetamine more after they've stopped using it for a while, using rats to explore how certain brain cells are involved in those cravings, which could help us understand and prevent relapses.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Texas A&m University NIH-funded |
| Lab location | 1 site (College Station, United States) |
| Project start | April 3, 2025 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $193,446 |
| NIH project number | 7K01DA058168-02 |
| Project ID | NIH-11311745 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of methamphetamine use who are currently in recovery or abstinence.
✕Less likely to help
Patients who have never used methamphetamine or those with other substance use disorders may not benefit from this research.
What this research studies
This research investigates the biological mechanisms that lead to increased craving for methamphetamine, particularly after periods of abstinence. Using a model involving rats, the study focuses on specific neurons in the brain that are involved in drug-seeking behavior. By employing advanced techniques like optogenetics and electrophysiology, the researchers aim to differentiate the roles of various types of neurons in the craving process. This could provide insights into how cravings intensify and potentially lead to relapse.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing relapse in individuals recovering from methamphetamine addiction.
How similar studies have gone: Previous research has shown promising results in understanding drug cravings through similar biological approaches, indicating potential for success in this area.
Where this research is happening
-
Texas A&m University
College Station, United States Active
Researchers
- Principal investigator: Swinford-Jackson, Sarah E. — Texas A&m University
- Study coordinator: Swinford-Jackson, Sarah E.
Related research
Other NIH-funded projects on the same topics.
-
Astrocyte Clock and Daily Rhythms in Brain Function and Memory
This project explores how the brain’s support cells (astrocytes) and their daily clock affect learning, memory, and cognitive health, especially in conditions like Alzheimer’s disease.
-
Spatial ML tools for huge maps of tissue biology
A high-tech project develops scalable computer methods to analyze very large, spatially-resolved tissue data from patients.
-
Mirror-image RNA-binding reagents to study and modulate RNA in the lab
A scientist-led project to develop mirror-image RNA-binding molecules (L-aptamers) that can target RNA structures with high precision for basic science and potential therapies.
-
Cerebellum changes in aging and cognitive decline
Researchers are studying how aging affects the cerebellum and how these brain changes relate to moments of cognitive decline in people aged 65 and older.
-
GPI-anchor biosynthesis and sleep: how our genes shape your sleep
This project looks at how a specific gene pathway influences sleep in people and animal models to understand why sleep disorders happen.
-
Bayesian modeling of single-cell spatial data to find meaningful patterns in circadian-related affective disorders
A research team will use advanced Bayesian methods on single-cell spatial data to uncover how circadian rhythm disruptions may affect brain and body signals linked to mood and aggression in people with affective disorders.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.