Understanding how methamphetamine affects brain health in people with HIV
The impact of methamphetamine on CXCL12 mediated HIV neuropathogenesis
['FUNDING_R01'] · ALBERT EINSTEIN COLLEGE OF MEDICINE · NIH-11090447
This research aims to understand how methamphetamine use contributes to brain problems in people living with HIV.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBERT EINSTEIN COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (BRONX, UNITED STATES) |
| Trial ID | NIH-11090447 on ClinicalTrials.gov |
What this research studies
This project seeks to uncover the specific ways methamphetamine use worsens brain health in individuals with HIV, even when they are receiving effective HIV treatment. It focuses on how certain immune cells, when infected with HIV, cross into the brain and cause inflammation and damage. By identifying the exact pathways involved, researchers hope to develop new strategies to protect the brain and improve cognitive function for people with HIV who also use methamphetamine. This work specifically looks at chemical signals that guide these immune cells into the brain.
Who could benefit from this research
Good fit: This research is relevant to people living with HIV who also have a methamphetamine use disorder and experience neurocognitive problems.
Not a fit: Patients who do not have HIV or do not use methamphetamine would likely not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments or strategies to prevent or reduce brain damage and cognitive difficulties for people living with HIV who use methamphetamine.
How similar studies have performed: While some foundational work on HIV and brain inflammation exists, this specific approach to understanding methamphetamine's role in this process is exploring novel mechanisms.
Where this research is happening
BRONX, UNITED STATES
- ALBERT EINSTEIN COLLEGE OF MEDICINE — BRONX, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BERMAN, JOAN WEINBERGER — ALBERT EINSTEIN COLLEGE OF MEDICINE
- Study coordinator: BERMAN, JOAN WEINBERGER
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus, Behavior Disorders