Understanding how metal-using enzymes work
Mapping the structural basis for mechanistic diversity in metalloenzyme superfamilies
['FUNDING_OTHER'] · PENNSYLVANIA STATE UNIVERSITY, THE · NIH-11086098
This project explores how enzymes that use metals perform important tasks in the body, including those related to bacterial infections and drug development.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PENNSYLVANIA STATE UNIVERSITY, THE (nih funded) |
| Locations | 1 site (UNIVERSITY PARK, UNITED STATES) |
| Trial ID | NIH-11086098 on ClinicalTrials.gov |
What this research studies
Our bodies rely on special enzymes that use metals to carry out complex chemical reactions, like building DNA. This project aims to uncover how these metal-dependent enzymes work, especially those involved in essential biological processes and those found in harmful bacteria. By understanding their structure and how they use metals, we hope to find new ways to block bacterial enzymes, which could lead to new treatments. We also want to learn how these enzymes can be used to create new drugs and other useful chemicals more efficiently.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future applications could benefit individuals with bacterial infections.
Not a fit: Patients seeking immediate treatment or direct clinical intervention will not find direct benefit from this basic science project.
Why it matters
Potential benefit: This work could lead to new strategies for developing drugs to fight bacterial infections and more efficient ways to produce medicines and other valuable chemicals.
How similar studies have performed: This project builds upon existing knowledge of metalloenzymes and aims to discover novel mechanisms and enzyme families.
Where this research is happening
UNIVERSITY PARK, UNITED STATES
- PENNSYLVANIA STATE UNIVERSITY, THE — UNIVERSITY PARK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: BOAL, AMIE K — PENNSYLVANIA STATE UNIVERSITY, THE
- Study coordinator: BOAL, AMIE K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.