Understanding how metal stress affects proteins in cells
Elucidating the Molecular Basis of Cellular Metal Stress by using Mass Spectrometry-Based Proteomic Methods
This study is looking at how too much metal in the body, like copper and zinc, can be harmful and affect certain proteins, which might help us understand diseases like cancer and brain disorders, so we can find better ways to manage metal levels for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11257480 on NIH RePORTER |
What this research studies
This research investigates how metal ions, which are essential for cell function, can become toxic when not properly regulated. By using advanced mass spectrometry techniques, the study aims to identify specific proteins that are impacted by excess levels of metals like copper and zinc. This could help uncover the mechanisms behind metal imbalances that contribute to diseases such as cancer and neurodegenerative disorders. Patients may benefit from insights gained about how to better manage metal levels in the body.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to metal imbalances, such as certain cancers or neurodegenerative diseases.
Not a fit: Patients who do not have issues related to metal ion regulation or who are not affected by the conditions being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating conditions related to metal imbalances, including cancer and neurodegenerative diseases.
How similar studies have performed: Previous research has shown promise in using mass spectrometry to study metal-protein interactions, indicating that this approach could yield valuable insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Franz, Katherine J. — Duke University
- Study coordinator: Franz, Katherine J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.