Understanding how metal stress affects proteins in cells
Elucidating the Molecular Basis of Cellular Metal Stress by using Mass Spectrometry-Based Proteomic Methods
This study is looking at how too much copper and zinc can mess with proteins in our cells, which might help us understand their role in diseases like cancer and brain disorders, so we can find better ways to manage metal levels in our bodies for better health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11013892 on NIH RePORTER |
What this research studies
This research investigates how excess metal ions, like copper and zinc, can disrupt protein function in cells. By using advanced mass spectrometry techniques, the study aims to identify specific proteins that become unstable under metal stress. This could help in understanding the role of metal imbalances in diseases such as cancer and neurodegenerative disorders. Patients may benefit from insights gained about how to better manage metal levels in the body to improve health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to metal imbalances, such as certain cancers or neurodegenerative diseases.
Not a fit: Patients without any known issues related to metal ion regulation or those not suffering from the targeted conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to metal imbalances, such as cancer and neurodegenerative conditions.
How similar studies have performed: Other research has shown promise in using mass spectrometry to study protein interactions with metals, indicating that this approach could yield valuable insights.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Franz, Katherine J. — Duke University
- Study coordinator: Franz, Katherine J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.