Understanding how metal ions interact with proteins
Modeling Transition Metal Ion Binding to Proteins
This study is working on creating better computer models to understand how important metal ions interact with proteins in our bodies, which could help us learn more about their role in health and diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cleveland Clinic Lerner Com-Cwru NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project ID | NIH-10880795 on NIH RePORTER |
What this research studies
This research focuses on improving the computational modeling of transition metal ions, which are crucial for many biological processes. By developing advanced software tools, the project aims to create accurate models that simulate how these metal ions bind to proteins and influence their functions. This could help address significant biological challenges, such as how metal ions affect enzyme activity and their role in diseases. The research will involve collaboration among various scientific groups to establish best practices in modeling these complex interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to metal ion dysregulation, such as certain metabolic disorders or infections.
Not a fit: Patients who do not have any known issues related to metal ions or who are not affected by conditions involving metalloproteins may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment of diseases related to metal ion imbalances in the body.
How similar studies have performed: While there has been some progress in modeling protein interactions, this specific focus on transition metal ions is relatively novel and has not been extensively tested.
Where this research is happening
Cleveland, United States
- Cleveland Clinic Lerner Com-Cwru — Cleveland, United States (Active)
Researchers
- Principal investigator: Merz, Kenneth M. — Cleveland Clinic Lerner Com-Cwru
- Study coordinator: Merz, Kenneth M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.