Understanding how metal-containing proteins control body processes and chemical reactions
Metalloprotein Mechanisms of Redox Regulation and Catalysis
This work explores how special proteins with metals inside them help regulate important chemical reactions in living things, from tiny microbes to humans, to discover new ways these processes work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-11097204 on NIH RePORTER |
What this research studies
Our bodies rely on tiny chemical reactions to function, and special proteins containing metals play a key role in controlling these processes. This research aims to uncover the hidden ways these 'metalloproteins' manage important reactions, especially those involving oxygen and other chemicals. We are looking at these mechanisms across different life forms, from simple microbes to complex human systems, to understand how they contribute to overall health. By learning more about these fundamental processes, we hope to find new insights that could one day lead to better health solutions.
Who could benefit from this research
Good fit: This foundational biological research does not directly involve patient participation, but its findings could eventually inform future clinical applications for a wide range of conditions.
Not a fit: Patients seeking immediate treatment or direct clinical intervention will not find direct benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could reveal entirely new biological mechanisms that have broad importance for human health, potentially leading to new ways to understand and treat diseases.
How similar studies have performed: This work builds upon recent discoveries in bioinorganic and enzymatic mechanisms, suggesting a foundation of prior successful research in related areas, while also exploring novel aspects.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Ragsdale, Stephen Wiley — University of Michigan at Ann Arbor
- Study coordinator: Ragsdale, Stephen Wiley
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.