Understanding how metabolites interact with proteins to regulate cellular functions.
Official title: Protein-metabolite interaction networks for functional characterization of metabolites.
Funded at Michigan State University · NIH-11095999 · Data updated 2026-11-12
This study is looking at how small molecules in our bodies interact with proteins to help control important processes, which could give us new insights into how metabolism works in different living things.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | June 1, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $384,052 |
| NIH project number | 5R35GM153298-02 |
| Project ID | NIH-11095999 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with metabolic disorders or conditions that may benefit from improved understanding of metabolic regulation.
✕Less likely to help
Patients with unrelated health conditions or those not affected by metabolic issues may not receive direct benefits from this research.
What this research studies
This research investigates the role of metabolites in regulating protein activities and cellular processes. By identifying protein-metabolite complexes, the study aims to uncover how these interactions influence metabolic adaptations in various organisms. The approach utilizes a novel biochemical method called PROMIS, which allows for the simultaneous analysis of proteins and their associated small-molecule ligands. This could lead to significant insights into the regulatory mechanisms of metabolism.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of metabolic regulation, potentially leading to new therapeutic strategies for metabolic disorders.
How similar studies have gone: Previous research has shown success in understanding protein-metabolite interactions, indicating that this approach has the potential for meaningful discoveries.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: Skirycz, Aleksandra — Michigan State University
- Study coordinator: Skirycz, Aleksandra
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.