Understanding how metabolites affect COPD symptoms and treatment
Official title: Leveraging Serum Metabolomics to Understand Clinical Phenotypes in COPD
Funded at University of Michigan at Ann Arbor · NIH-10874755 · Data updated 2026-11-12
This study is looking at how tiny molecules in your body, called metabolites, can help us understand the different symptoms and experiences of people with COPD, so we can create more personalized treatments just for you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | July 1, 2020 |
| Project end | October 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $174,960 |
| NIH project number | 5K23HL151751-05 |
| Project ID | NIH-10874755 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic obstructive pulmonary disease (COPD) who are willing to provide blood samples for metabolomic analysis.
✕Less likely to help
Patients without a diagnosis of COPD or those who are not able to provide blood samples may not benefit from this research.
What this research studies
This research investigates the role of metabolites, which are small molecules found in the body, in understanding the diverse symptoms and outcomes of chronic obstructive pulmonary disease (COPD). By analyzing blood samples from patients, the study aims to identify specific metabolite profiles that correlate with different clinical manifestations of COPD. This could lead to more personalized treatment strategies based on individual metabolic profiles, ultimately improving patient care and outcomes. The research will be conducted over five years, with a focus on training the principal investigator in both clinical and translational research methodologies.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for patients with COPD.
How similar studies have gone: Other research has shown promising results in using metabolomics to understand various diseases, suggesting that this approach could be beneficial for COPD as well.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Labaki, Wassim W — University of Michigan at Ann Arbor
- Study coordinator: Labaki, Wassim W
Related research
Other NIH-funded projects on the same topics.
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Understanding COPD by linking genes, metabolites, and the body’s signals
A study using blood and lung data to map how genetic factors and metabolism drive COPD, with the goal of finding new targets for treatment.
-
Omalizumab for COPD patients with allergen sensitization and exposure
A multicenter trial will test whether adding omalizumab helps people with COPD who are allergic to common indoor allergens and are exposed to them.
-
Newborn screening: using gene and metabolite data to refine true vs false positives
A study using genetic and metabolomic data from newborn blood spots to better distinguish real metabolic disorders from false alarms.
-
Clinical CT Imaging to identify and subtype pulmonary hypertension in COPD
A new CT imaging approach aims to help doctors detect and classify pulmonary hypertension in people with COPD.
-
Next-Generation Wearable AI for Precision COPD Risk and Care
A patient-centered project uses a smart wearable and AI to predict COPD flare-ups and support doctors in making better care decisions.
-
Ethics-aware Multimodal AI for COPD prevention, diagnosis, and treatment
A broad AI model uses diverse health data to help predict and manage COPD in people, with an emphasis on ethics and fairness.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.