Understanding how metabolism affects the production of tiny vesicles called exosomes
Metabolic regulation of exosome biogenesis
This study is looking at how our body's metabolism affects tiny particles called exosomes that carry important information, with the goal of finding better ways to diagnose and treat brain injuries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10877935 on NIH RePORTER |
What this research studies
This research investigates the role of metabolism in the production of exosomes, which are small vesicles secreted by cells that carry important biomolecules. By examining how different metabolic conditions influence the rate and content of exosome generation, the study aims to enhance our understanding of their potential as biomarkers and therapeutic agents, particularly in the context of brain injuries. The research will involve manipulating nutrient and NAD levels to observe their effects on exosome biogenesis, and it will also develop advanced technologies for sorting these vesicles. Patients may benefit from improved diagnostic and treatment strategies for conditions related to exosome function.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with acquired brain injuries or those interested in innovative therapies involving exosomes.
Not a fit: Patients with conditions unrelated to exosome function or those not experiencing metabolic dysregulation may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatments for brain injuries and other conditions through the use of exosomes.
How similar studies have performed: Previous research has shown promise in using exosomes from mesenchymal stem cells for treating brain injuries, indicating a potential for success in this area.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Jeong, Sangmoo — Johns Hopkins University
- Study coordinator: Jeong, Sangmoo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.