Understanding how metabolism affects the immune response to shingles vaccines
ImmunoMetabolomics of Zoster Vaccines
This study is looking at how your body's metabolism affects how well the herpes zoster vaccine, Zostavax, works, and it's for anyone interested in understanding more about vaccines and how to make them better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project ID | NIH-10740860 on NIH RePORTER |
What this research studies
This research investigates the relationship between metabolism and immune responses to the herpes zoster vaccine, Zostavax. By analyzing blood samples from participants, the team aims to identify specific metabolites that influence how well the vaccine works. They will develop predictive models based on these metabolic profiles and test them on different cohorts. The findings could help improve vaccine efficacy and inform future vaccine development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are receiving or have received the herpes zoster vaccine.
Not a fit: Patients who have not received the herpes zoster vaccine or those with contraindications to vaccination may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines for shingles and potentially other infectious diseases.
How similar studies have performed: Previous studies have shown promise in using metabolomics to understand immune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
Bar Harbor, United States
- Jackson Laboratory — Bar Harbor, United States (Active)
Researchers
- Principal investigator: Li, Shuzhao — Jackson Laboratory
- Study coordinator: Li, Shuzhao
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.