Understanding how metabolism affects red blood cell production
Official title: Defining the metabolic regulation of erythropoiesis
Funded at University of Michigan at Ann Arbor · NIH-11051765 · Data updated 2026-11-12
This study is looking at how energy processes help stem cells turn into red blood cells, which is important for people with anemia, and it uses both mice and human cells to understand how this works.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $42,094 |
| NIH project number | 5F31HL172674-02 |
| Project ID | NIH-11051765 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with anemia or other blood disorders related to red blood cell production.
✕Less likely to help
Patients with conditions unrelated to red blood cell production or those who do not have anemia may not benefit from this research.
What this research studies
This research investigates the role of metabolic processes in the development of red blood cells from hematopoietic stem cells. It focuses on a specific mechanism called the malate-aspartate shuttle, which is crucial for energy transfer within cells. By using both mouse models and human stem cells, the research aims to identify the stages of red blood cell development that rely on this metabolic pathway and to uncover the molecular mechanisms involved. The findings could provide insights into conditions like anemia, where red blood cell production is impaired.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for anemia and other blood disorders by enhancing our understanding of red blood cell production.
How similar studies have gone: Previous research has shown that metabolic regulation plays a significant role in blood cell development, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Pourmandi, Narges — University of Michigan at Ann Arbor
- Study coordinator: Pourmandi, Narges
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.