Understanding how metabolism affects red blood cell production
Official title: Metabolic Regulation of erythropoiesis
Funded at Pennsylvania State University, the · NIH-10902000 · Data updated 2026-11-12
This study is looking at how things like inflammation can affect your body's ability to make red blood cells, especially if you have anemia, and it hopes to find new ways to help improve red blood cell production for people dealing with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $299,011 |
| NIH project number | 5R01DK138865-05 |
| Project ID | NIH-10902000 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals experiencing anemia, particularly those with inflammation-related anemia.
✕Less likely to help
Patients with anemia due to intrinsic defects in erythroid progenitor cells may not benefit from this research.
What this research studies
This research investigates the mechanisms by which metabolic processes influence the production of red blood cells, particularly in the context of anemia. It focuses on how inflammation and other external factors can disrupt normal erythropoiesis, leading to various forms of anemia. The study aims to identify key cellular populations involved in stress erythropoiesis, which is a compensatory response to inflammation. By examining these processes, the research seeks to uncover potential therapeutic targets for improving red blood cell production in affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for anemia, improving the quality of life for patients suffering from this condition.
How similar studies have gone: Previous research has shown promising results in understanding stress erythropoiesis, indicating that this approach has potential for significant advancements in anemia treatment.
Where this research is happening
-
Pennsylvania State University, the
University Park, United States Active
Researchers
- Principal investigator: Paulson, Robert Frank — Pennsylvania State University, the
- Study coordinator: Paulson, Robert Frank
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.