Understanding how metabolism affects pancreatic cell changes and cancer development
Official title: Metabolic regulation of pancreatic metaplasia and neoplasia
Funded at University of Michigan at Ann Arbor · NIH-10985624 · Data updated 2026-11-12
This study is looking at how changes in the way cells use energy might help certain pancreatic cells change into a different type of cell, which could be important for understanding early signs of pancreatic cancer, and it aims to find ways to prevent it.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 6, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $125,000 |
| NIH project number | 1K99GM159354-01A1 |
| Project ID | NIH-10985624 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for pancreatic cancer, particularly those with a history of pancreatic injury or genetic predispositions.
✕Less likely to help
Patients with established pancreatic cancer or those without any risk factors for pancreatic disease may not benefit from this research.
What this research studies
This research investigates how changes in cell metabolism influence the transformation of pancreatic acinar cells into duct-like cells, a process known as acinar-to-ductal metaplasia (ADM). The study aims to understand the metabolic alterations that occur during this process and how they may contribute to the development of pancreatic cancer. By using genetically engineered mouse models and advanced metabolic analysis techniques, the researchers will explore the role of specific enzymes and metabolic pathways in regulating these cellular changes. Patients may benefit from insights gained about the early stages of pancreatic cancer and potential preventive strategies.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing pancreatic cancer by targeting metabolic processes involved in early cell changes.
How similar studies have gone: Previous research has shown promising results in understanding metabolic changes in cancer, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Radyk, Megan Deanna — University of Michigan at Ann Arbor
- Study coordinator: Radyk, Megan Deanna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.