Understanding how metabolism affects mitochondrial protein production
Official title: Metabolic control of mitonuclear balance for OXPHOS protein biogenesis
Funded at Harvard Medical School · NIH-10997686 · Data updated 2026-11-12
This study is looking at how our cells make energy and proteins that keep our mitochondria working well, which is important for everyone’s health, especially for those with mitochondrial disorders or neurodegenerative diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard Medical School NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $73,828 |
| NIH project number | 1F32GM156063-01 |
| Project ID | NIH-10997686 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with mitochondrial dysfunction or related metabolic disorders.
✕Less likely to help
Patients with conditions unrelated to mitochondrial function or metabolism may not benefit from this research.
What this research studies
This research investigates the relationship between cellular metabolism and the production of proteins essential for mitochondrial function. It focuses on the coordination between nuclear and mitochondrial genomes, which is crucial for the assembly of oxidative phosphorylation (OXPHOS) complexes. By utilizing advanced CRISPR screening techniques, the study aims to identify new factors that regulate the biogenesis of these proteins, which, if disrupted, can lead to serious health issues like mitochondrial disorders and neurodegeneration. Patients may benefit from insights gained into how metabolic factors influence mitochondrial health.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for mitochondrial disorders and related metabolic conditions.
How similar studies have gone: Previous research has shown promising results in understanding metabolic influences on mitochondrial function, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Harvard Medical School
Boston, United States Active
Researchers
- Principal investigator: Raicu, Ana-Maria — Harvard Medical School
- Study coordinator: Raicu, Ana-Maria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.