Understanding how metabolism affects lymphatic vessels
Metabolic mechanisms controlling lymphatic vessel formation
This research explores how the body's energy use influences the growth of lymphatic vessels, which could help in treating cancer and improving organ transplants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-11110507 on NIH RePORTER |
What this research studies
Lymphatic vessels are important for fluid balance, fat absorption, and cholesterol transport in the body. Their growth is often driven by a signal called VEGF-C, which can also cause harmful lymphatic growth in conditions like cancer and after organ transplants. This project aims to understand how VEGF-C signaling uses a unique energy process, known as the Warburg effect, to promote lymphatic vessel growth. By learning more about these metabolic pathways, we hope to find new ways to stop unwanted lymphatic vessel growth in diseases.
Who could benefit from this research
Good fit: This foundational research is not directly recruiting patients, but future clinical applications could benefit individuals with certain cancers or those undergoing organ transplantation.
Not a fit: Patients without conditions related to lymphatic vessel growth, cancer, or organ transplantation are unlikely to directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to new treatments that target lymphatic vessel growth to prevent cancer spread or improve the success of organ transplants.
How similar studies have performed: This project builds upon previous discoveries about lymphatic cell metabolism and preliminary findings, suggesting a novel approach to understanding lymphatic vessel growth.
Where this research is happening
Oklahoma City, United States
- Oklahoma Medical Research Foundation — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Yu, Pengchun — Oklahoma Medical Research Foundation
- Study coordinator: Yu, Pengchun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.