Understanding how metabolism affects lung cancer progression
Official title: Metabolic control of malignant fates in lung cancer
Funded at Sloan-Kettering Inst Can Research · NIH-11029740 · Data updated 2026-11-12
This study is looking at how different ways cancer cells use energy in lung adenocarcinoma, a common type of lung cancer, to see if changing these energy pathways can help make treatments work better for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 1, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $730,400 |
| NIH project number | 1R01CA297077-01 |
| Project ID | NIH-11029740 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with lung adenocarcinoma, particularly those experiencing treatment resistance.
✕Less likely to help
Patients with other types of lung cancer or those who are not diagnosed with adenocarcinoma may not benefit from this research.
What this research studies
This research investigates the role of metabolic pathways in lung adenocarcinoma (LUAD), a common and deadly form of lung cancer. It focuses on how different cell states within tumors may have varying metabolic preferences that influence their ability to progress and resist treatment. By manipulating specific metabolic pathways, particularly the tricarboxylic acid (TCA) cycle, the researchers aim to determine if targeting these pathways can help differentiate or de-differentiate cancer cells, potentially leading to more effective treatments. The study uses both mouse and human cell lines to explore these metabolic configurations and their implications for cancer treatment.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that specifically target the metabolic vulnerabilities of lung cancer cells, improving treatment outcomes.
How similar studies have gone: Other research has shown promising results in targeting metabolic pathways in cancer treatment, suggesting that this approach may be effective.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Finley, Lydia — Sloan-Kettering Inst Can Research
- Study coordinator: Finley, Lydia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.