Understanding how metabolism affects immune cell balance in brain autoimmune diseases
Metabolic regulators of Treg/Th17 balance in CNS autoimmunity
['FUNDING_R01'] · BRIGHAM AND WOMEN'S HOSPITAL · NIH-10890664
This study is looking at how certain immune cells work together in people with autoimmune diseases that affect the brain and nervous system, using advanced computer tools to understand their behavior better, with the hope of finding new ways to help balance the immune response and reduce inflammation.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BRIGHAM AND WOMEN'S HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10890664 on ClinicalTrials.gov |
What this research studies
This research investigates the balance between different types of immune cells, specifically regulatory T cells and Th17 cells, in the context of autoimmune diseases affecting the central nervous system. It utilizes a novel computational algorithm to analyze single-cell RNA sequencing data, allowing researchers to predict the metabolic states of these cells. By exploring how metabolic factors influence immune responses, the study aims to identify potential therapeutic targets that could restore balance and reduce inflammation in affected tissues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with autoimmune conditions affecting the central nervous system, such as multiple sclerosis.
Not a fit: Patients with autoimmune diseases not affecting the central nervous system or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help manage or prevent autoimmune diseases in the central nervous system.
How similar studies have performed: Other research has shown promising results in manipulating immune cell metabolism to influence autoimmune responses, suggesting that this approach may be effective.
Where this research is happening
BOSTON, UNITED STATES
- BRIGHAM AND WOMEN'S HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KUCHROO, VIJAY K. — BRIGHAM AND WOMEN'S HOSPITAL
- Study coordinator: KUCHROO, VIJAY K.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.