Understanding how metabolism affects gene regulation through bromodomains
Discovering and Exploiting Selectivity within Tandem Bromodomains
This study is looking at how certain proteins help control gene activity and how changes in metabolism and genetics can affect this process, with the goal of finding new treatments for diseases like cancer and heart problems.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11018528 on NIH RePORTER |
What this research studies
This research investigates the role of bromodomains in reading epigenetic signals that regulate gene expression, particularly how these processes are influenced by metabolic changes and genetic variants associated with diseases. The team employs a multidisciplinary approach, combining biochemistry and drug development to create new chemical tools aimed at targeting bromodomains. By exploring how different acylations on histones affect transcription, the research aims to uncover mechanisms that could lead to new treatments for conditions like cancer and cardiovascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with cancer or cardiovascular diseases who may benefit from targeted therapies that modulate gene expression.
Not a fit: Patients with conditions unrelated to bromodomain function or those not affected by metabolic dysregulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that improve treatment outcomes for patients with cancer and cardiovascular diseases.
How similar studies have performed: Previous research has shown promise in targeting bromodomains for cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Smith, Brian Christopher — Medical College of Wisconsin
- Study coordinator: Smith, Brian Christopher
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.