Understanding how metabolism affects gene regulation in cells
Eavesdropping on the conversation between chromatin and metabolism
['FUNDING_OTHER'] · UNIVERSITY OF UTAH · NIH-11092774
This study is looking at how our body's metabolism affects the way our genes work, especially by using special sensors to measure important chemicals that help with this process, which could lead to new ways to understand and treat various health issues related to metabolism.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF UTAH (nih funded) |
| Locations | 1 site (SALT LAKE CITY, UNITED STATES) |
| Trial ID | NIH-11092774 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between metabolism and gene expression by focusing on how certain chemical modifications to histones, known as acylations, are influenced by metabolic signals. The team is developing innovative biosensors to track acyl-CoA levels, which are crucial for these modifications. By exploring how these metabolic changes impact the regulation of genes, the research aims to uncover new insights into disease mechanisms and potential therapeutic targets. This work is particularly relevant as metabolic dysregulation is linked to many health conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to metabolic disorders or epigenetic changes.
Not a fit: Patients with stable metabolic health and no epigenetic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases associated with metabolic dysregulation.
How similar studies have performed: Other research has shown promising results in understanding the links between metabolism and gene regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
SALT LAKE CITY, UNITED STATES
- UNIVERSITY OF UTAH — SALT LAKE CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DIEHL, KATHARINE — UNIVERSITY OF UTAH
- Study coordinator: DIEHL, KATHARINE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.