Understanding how metabolism affects gene regulation and cancer development
Revealing the crosstalk between one carbon metabolism, SAM availability and chromatin methylation
This study is looking at how changes in metabolism can affect gene activity in cancer, focusing on a protein called SIRT6 that helps regulate these processes, which could lead to new ways to understand and treat different types of cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11089086 on NIH RePORTER |
What this research studies
This research investigates the relationship between metabolic processes and chromatin modifications, specifically focusing on how metabolites influence gene regulation in cancer. The study examines the role of SIRT6, a protein that modifies chromatin, in controlling metabolic homeostasis and its implications for tumor suppression. By exploring the connections between metabolism and epigenetics, the research aims to uncover new insights into cancer heterogeneity and potential therapeutic targets. Patients may benefit from a deeper understanding of how metabolic changes can affect cancer progression and treatment responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with various types of cancer, particularly those exhibiting metabolic dysregulation.
Not a fit: Patients with non-cancerous conditions or those not experiencing metabolic issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for cancer treatment by targeting metabolic pathways.
How similar studies have performed: Previous research has shown promising results in understanding the interplay between metabolism and gene regulation, indicating that this approach could yield significant insights.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Mostoslavsky, Raul — Massachusetts General Hospital
- Study coordinator: Mostoslavsky, Raul
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.