Understanding how metabolism affects gene regulation and cancer development
Official title: Revealing the crosstalk between one carbon metabolism, SAM availability and chromatin methylation
Funded at Massachusetts General Hospital · NIH-11089086 · Data updated 2026-11-12
This study is looking at how changes in metabolism can affect gene activity in cancer, focusing on a protein called SIRT6 that helps regulate these processes, which could lead to new ways to understand and treat different types of cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | June 1, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $453,750 |
| NIH project number | 1R35GM158046-01 |
| Project ID | NIH-11089086 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with various types of cancer, particularly those exhibiting metabolic dysregulation.
✕Less likely to help
Patients with non-cancerous conditions or those not experiencing metabolic issues may not benefit from this research.
What this research studies
This research investigates the relationship between metabolic processes and chromatin modifications, specifically focusing on how metabolites influence gene regulation in cancer. The study examines the role of SIRT6, a protein that modifies chromatin, in controlling metabolic homeostasis and its implications for tumor suppression. By exploring the connections between metabolism and epigenetics, the research aims to uncover new insights into cancer heterogeneity and potential therapeutic targets. Patients may benefit from a deeper understanding of how metabolic changes can affect cancer progression and treatment responses.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for cancer treatment by targeting metabolic pathways.
How similar studies have gone: Previous research has shown promising results in understanding the interplay between metabolism and gene regulation, indicating that this approach could yield significant insights.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Mostoslavsky, Raul — Massachusetts General Hospital
- Study coordinator: Mostoslavsky, Raul
Related research
Other NIH-funded projects on the same topics.
-
Global TravEpiNet: Pregnant Travelers Health and Disease Prevention Network
This grant supports a national network to improve health and prevent infections among international travelers, with a special focus on pregnant travelers.
-
Soluble ST2 and the course of lung injury in ARDS
A doctor-scientist at a top hospital is studying how a molecule called soluble ST2 may influence how lung injury starts and heals in patients with ARDS and related conditions.
-
Role of airway macrophages in lung health and allergic disease
A doctor-scientist at a major hospital wants to study how immune cells in the airways develop and influence asthma and other airway diseases.
-
Global TravEpiNet: Understanding and Protecting US Travelers, including Pregnant Travelers
A large U.S. network studies international travelers, including pregnant travelers, to understand illness risks and reduce the spread of infections.
-
Gait speed from wearable sensors to guide ALS trials
A patient-friendly look at using wearable sensors to measure how fast people with ALS walk, to help run better ALS trials.
-
Determinants of Post-Stroke Cognitive Outcomes and Vascular Effects on Recovery
A large, multi-site effort aims to understand why some stroke survivors develop long-term cognitive problems and dementia, and how vascular health and pre-existing brain changes influence recovery.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.