Understanding how metabolism affects blood vessel health in cardiovascular disease
Official title: Endothelial Metabolism and Redox Imbalance in Vascular Disease
Funded at Augusta University · NIH-11103131 · Data updated 2026-11-12
This study is looking at how changes in the way cells use energy can affect blood vessel health, which is important for people with heart conditions like atherosclerosis and high blood pressure, and it hopes to find new ways to help improve heart health.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Augusta University NIH-funded |
| Lab location | 1 site (Augusta, United States) |
| Project start | June 5, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $2,264,097 |
| NIH project number | 5P01HL160557-02 |
| Project ID | NIH-11103131 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with cardiovascular diseases such as atherosclerosis, hypertension, or peripheral arterial disease.
✕Less likely to help
Patients without cardiovascular disease or those with unrelated health conditions may not benefit from this research.
What this research studies
This research investigates the imbalance of reactive oxygen and nitrogen species in endothelial cells, which are crucial for maintaining healthy blood vessels. It aims to uncover how changes in cellular metabolism contribute to conditions like atherosclerosis and hypertension. By exploring the metabolic pathways of endothelial cells, the study seeks to identify new strategies for improving cardiovascular health. Patients may benefit from insights that could lead to more effective treatments for cardiovascular diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for preventing and treating cardiovascular diseases.
How similar studies have gone: Previous research has shown promise in understanding metabolic pathways in endothelial cells, but this specific approach to redox imbalance is relatively novel.
Where this research is happening
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Augusta University
Augusta, United States Active
Researchers
- Principal investigator: Fukai, Tohru — Augusta University
- Study coordinator: Fukai, Tohru
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.