Understanding How Metabolism Affects Asthma
Evaluating the Impact of Metabolic Dysfunction on Asthma Pathology and Physiology
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-11092734
This research explores how metabolic issues, often linked to obesity, might make asthma worse for some adults.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-11092734 on ClinicalTrials.gov |
What this research studies
More than 40% of adult Americans are obese, and many with severe asthma also experience obesity. This project looks into how metabolic dysfunction, like insulin resistance, might be connected to more severe asthma and why some obese asthma patients don't respond well to common asthma medications. We will carefully examine lung function and other health markers in obese asthma patients, both with and without metabolic dysfunction. This work aims to uncover the specific ways metabolic health influences asthma severity and treatment response.
Who could benefit from this research
Good fit: Ideal candidates are adults aged 21 and older who have asthma and obesity, particularly those who may also have metabolic dysfunction.
Not a fit: Patients who do not have asthma, are not obese, or do not have metabolic dysfunction may not directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this research could lead to new ways to treat severe asthma, especially for obese patients whose current medications are not working well.
How similar studies have performed: Prior research has shown a link between metabolic dysfunction and more severe asthma, providing a strong foundation for this new investigation into the underlying mechanisms.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FAHY, JOHN V — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: FAHY, JOHN V
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Airway Disease