Understanding how metabolism affects Alzheimer's disease through gene regulation
Official title: Gene regulatory mechanisms connecting metabolism and Alzheimer’s Disease
Funded at University of Utah · NIH-10660149 · Data updated 2026-11-12
This study is looking at how our body's metabolism might be linked to Alzheimer's disease by exploring certain genes that could help us understand the condition better, with the goal of finding new ways to slow it down or prevent it.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $2,307,286 |
| NIH project number | 1RF1AG077201-01A1 |
| Project ID | NIH-10660149 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are at risk for or diagnosed with Alzheimer's disease.
✕Less likely to help
Patients with early-stage Alzheimer's disease or those without any genetic predisposition to the condition may not benefit from this research.
What this research studies
This research investigates the connection between metabolism and Alzheimer's disease by focusing on gene regulatory mechanisms. It aims to identify specific cis-regulatory elements (CREs) that play a crucial role in gene expression related to Alzheimer's. Using an innovative approach called pPR-Seq, the study will profile active CREs and their interactions with genes in the brain. By uncovering these connections, the research hopes to find new ways to slow or prevent the progression of Alzheimer's disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or slowing the progression of Alzheimer's disease.
How similar studies have gone: Other research has shown promise in exploring the relationship between metabolism and Alzheimer's disease, but this specific approach is innovative and largely untested.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Gregg, Chris — University of Utah
- Study coordinator: Gregg, Chris
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.