Understanding how metabolism affects Alzheimer's disease
Metabolism of Alzheimer’s Disease: systems and cellular networks
This study is looking at how eating less might help protect the brain from Alzheimer's disease by checking how it affects brain function and cell interactions in mice that have a similar condition, with hopes of finding new ways to slow down the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-10838450 on NIH RePORTER |
What this research studies
This research investigates the role of metabolism in the progression of Alzheimer's disease (AD) by examining how caloric restriction (CR) may protect the brain from AD-related damage. Using mouse models that mimic human AD, the study will explore how CR influences brain metabolism and its effects on neuronal and glial cell interactions. Researchers will employ various techniques, including behavioral tests and advanced imaging, to track changes in brain function and structure. The goal is to uncover mechanisms that could lead to new therapeutic strategies for slowing down AD pathology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for Alzheimer's disease or those in the early stages of cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or those who do not meet the criteria for early-stage cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new interventions that slow the progression of Alzheimer's disease and improve cognitive function in affected individuals.
How similar studies have performed: Previous research has shown promising results in using caloric restriction and metabolic interventions to influence neurodegenerative processes, suggesting potential for success in this approach.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Anderson, Rozalyn M. — University of Wisconsin-Madison
- Study coordinator: Anderson, Rozalyn M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.