Understanding How Metabolism Affects Aging Skin
Metabolic Reprogramming and Regeneration in the Aged Epidermis
This project explores how changes in metabolism impact the skin's ability to repair and renew itself as we get older.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11112466 on NIH RePORTER |
What this research studies
Our skin naturally loses some of its protective and regenerative abilities as we age. This project aims to understand why this happens by focusing on the special stem cells in our skin that help it renew itself. We believe that changes in how these stem cells use energy, called metabolic reprogramming, are key to maintaining healthy skin. By learning why these metabolic changes are less effective in older skin, we hope to discover new ways to support skin health and its ability to repair itself.
Who could benefit from this research
Good fit: This research is foundational and does not directly involve patient participation, but future studies stemming from this work would likely focus on adults experiencing age-related skin changes.
Not a fit: Patients seeking immediate treatments for skin conditions would not directly benefit from this foundational research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to support skin health and its ability to repair itself as people age.
How similar studies have performed: Previous studies have not fully explained the molecular changes in aging skin, making this approach to understanding metabolic reprogramming in stem cells a novel direction.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Mandinova, Anna — Brigham and Women's Hospital
- Study coordinator: Mandinova, Anna
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.