Understanding how metabolism affects aging and DNA changes
Metabolic regulation of human DNA methylation clocks
This study is looking at how our body's energy production affects the way our cells age, using skin cells to understand how stress and metabolism might change markers of aging, which could help us find ways to age healthier.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10766187 on NIH RePORTER |
What this research studies
This research investigates the relationship between metabolic factors and biological aging, focusing on how mitochondrial function influences DNA methylation patterns associated with aging. By using a model of human fibroblast cells, the study aims to uncover the mechanisms behind aging clocks that predict lifespan and age-related diseases. The researchers will analyze how metabolic dysfunction and stress impact these aging markers over time, providing insights into potential interventions for healthier aging.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who may be experiencing age-related health issues or are interested in understanding their biological aging process.
Not a fit: Patients with acute or severe health conditions unrelated to aging or metabolic function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for promoting healthier aging and reducing age-related diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of mitochondrial function in aging, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC — New York, United States (Active)
Researchers
- Principal investigator: Picard, Martin — New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC
- Study coordinator: Picard, Martin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.