Understanding how metabolic signaling affects atrial fibrillation
Metabolic signaling in atrial fibrillation and remodeling
This study is looking at how metabolic stress affects atrial fibrillation, a common heart issue, to find new ways to help people, especially those with conditions like aging, diabetes, or heart failure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10805519 on NIH RePORTER |
What this research studies
This research investigates the role of metabolic stress in atrial fibrillation (AF), a common heart condition. It focuses on how metabolic pathways, particularly the AMPK signaling pathway, influence the structural and electrical properties of the heart's atria. By examining the mechanisms behind metabolic stress and its connection to AF, the study aims to identify new targets for treatment. Patients with conditions like aging, diabetes, and heart failure may be particularly relevant to this research.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with atrial fibrillation, especially those with underlying conditions such as diabetes or heart failure.
Not a fit: Patients without atrial fibrillation or those who do not have metabolic stress-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies for preventing and treating atrial fibrillation.
How similar studies have performed: Previous research has shown promising results in understanding metabolic pathways related to heart conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Young, Lawrence H — Yale University
- Study coordinator: Young, Lawrence H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.