Understanding how metabolic dysfunction in the brain affects Alzheimer's disease
Imaging and Reversibility of Cellular and Network Metabolic Dysfunction in Alzheimer's Disease
This study is looking at how Alzheimer's disease affects the brain's metabolism and cell function, using special imaging techniques to see if the changes caused by amyloid plaques can be reversed, which could help us find new ways to treat the disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-10536491 on NIH RePORTER |
What this research studies
This research investigates the metabolic changes that occur in the brain due to Alzheimer's disease, focusing on how these changes affect different cell types and overall brain function. By using advanced imaging techniques, the study aims to identify how amyloid plaques influence cellular metabolism and whether these changes can be reversed. The research will involve detailed assessments of brain metabolism in animal models, providing insights into the early stages of Alzheimer's disease and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or in the early stages of Alzheimer's disease.
Not a fit: Patients with advanced Alzheimer's disease or other forms of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating Alzheimer's disease by targeting metabolic dysfunction.
How similar studies have performed: Previous research has shown promising results in understanding metabolic dysfunction in Alzheimer's, but this approach aims to provide novel insights into cellular mechanisms.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Goyal, Manu S — Washington University
- Study coordinator: Goyal, Manu S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.