Understanding how metabolic control affects protein production in brain tumors
Official title: Metabolic control of tRNA-mediated translational reprogramming in glioblastoma
Funded at University of Pittsburgh at Pittsburgh · NIH-11070199 · Data updated 2026-11-12
This study is looking at how glioblastoma stem cells, which help tumors grow and resist treatment, make proteins and how controlling their metabolism might lead to new ways to help patients with this aggressive brain cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $83,224 |
| NIH project number | 5F32CA284780-02 |
| Project ID | NIH-11070199 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with glioblastoma who are seeking new treatment options.
✕Less likely to help
Patients with other types of brain tumors or those who are not adults may not benefit from this research.
What this research studies
This research investigates the role of metabolic control in the way certain cells in glioblastoma, a type of aggressive brain cancer, produce proteins. By focusing on glioblastoma stem cells, which are known to contribute to tumor growth and resistance to treatment, the study aims to uncover how these cells use specific mechanisms to enhance their protein synthesis. The approach involves examining the modifications of transfer RNAs (tRNAs) that are crucial for translating genetic information into proteins, potentially leading to new therapeutic strategies for patients with glioblastoma.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that more effectively target glioblastoma and improve patient outcomes.
How similar studies have gone: Previous research has shown promise in targeting metabolic pathways in cancer treatment, suggesting that this approach could yield beneficial results.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Duan, Tingting — University of Pittsburgh at Pittsburgh
- Study coordinator: Duan, Tingting
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.