Understanding how metabolic control affects insulin production in diabetes
Official title: Metabolic control of beta-cell secretory organelle function
Funded at University of Iowa · NIH-10937299 · Data updated 2026-11-12
This study is looking at how problems with insulin production in Type 2 diabetes happen and how managing your metabolism can help, with the goal of finding new ways to improve insulin secretion for better treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $449,864 |
| NIH project number | 1R01DK140093-01 |
| Project ID | NIH-10937299 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Type 2 diabetes who experience issues with insulin production.
✕Less likely to help
Patients with Type 1 diabetes or those without any form of diabetes may not benefit from this research.
What this research studies
This research investigates the mechanisms behind beta-cell dysfunction in Type 2 diabetes, focusing on how metabolic control influences insulin production. It aims to uncover the cellular processes that lead to defects in insulin trafficking and storage, which are critical in the progression of diabetes. By studying the role of endoplasmic reticulum (ER) redox homeostasis, the research seeks to identify potential therapeutic targets to restore normal beta-cell function. Patients may benefit from insights that could lead to new treatments aimed at improving insulin secretion.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that restore insulin production in patients with Type 2 diabetes.
How similar studies have gone: Previous research has shown promising results in understanding beta-cell dysfunction and its implications for diabetes treatment, suggesting that this approach has potential for success.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Stephens, Samuel Brandon — University of Iowa
- Study coordinator: Stephens, Samuel Brandon
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.