Understanding how metabolic changes affect prostate cancer in African American men
Identification of metabolic adducts associated with prostate cancer progression in African American men Supplement
This study is looking at why African American men have higher rates of prostate cancer by examining certain changes in their bodies that might lead to cancer, and it hopes to use this information to create better tests and treatments for them, with the help of volunteers who can provide samples.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-10993692 on NIH RePORTER |
What this research studies
This research investigates the biological changes that contribute to the higher rates of prostate cancer in African American men. It focuses on identifying specific metabolic adducts, particularly those related to a compound called methylglyoxal, which may lead to DNA mutations and cancer progression. By analyzing how these metabolic changes affect cellular processes, the research aims to develop better diagnostic and treatment options tailored for this population. Patients may be involved in providing biological samples to help identify these metabolic markers.
Who could benefit from this research
Good fit: Ideal candidates for this research are African American men who are at risk for or diagnosed with prostate cancer.
Not a fit: Patients who are not African American or those without a diagnosis or risk factors for prostate cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tests and personalized treatments for prostate cancer in African American men.
How similar studies have performed: Previous research has shown that understanding metabolic changes can lead to significant advancements in cancer treatment, suggesting a promising avenue for this investigation.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Shuck, Sarah C. — Beckman Research Institute/city of Hope
- Study coordinator: Shuck, Sarah C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.