Understanding how metabolic changes affect prostate cancer in African American men
Official title: Identification of metabolic adducts associated with prostate cancer progression in African American men
Funded at Beckman Research Institute/city of Hope · NIH-10721809 · Data updated 2026-11-12
This study is looking at why African American men have higher rates of prostate cancer by examining certain changes in their bodies that might lead to the disease, and it hopes to use this information to create better tests and treatments for prostate cancer, with the help of patients who can provide samples.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project start | September 22, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $466,478 |
| NIH project number | 1R21CA282612-01 |
| Project ID | NIH-10721809 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are African American men who are at risk for or diagnosed with prostate cancer.
✕Less likely to help
Patients who are not African American or those without a diagnosis of prostate cancer may not benefit from this research.
What this research studies
This research investigates the biological changes that contribute to the higher rates of prostate cancer in African American men. It focuses on identifying specific metabolic adducts, particularly those formed by a compound called methylglyoxal, which may lead to DNA mutations and cancer progression. By analyzing these metabolic changes, the study aims to develop better diagnostic tests and personalized treatments for prostate cancer. Patients may be involved in providing biological samples to help identify these metabolic markers.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and treatment options specifically tailored for African American men with prostate cancer.
How similar studies have gone: Previous research has indicated that metabolic changes play a significant role in cancer progression, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Beckman Research Institute/city of Hope
Duarte, United States Active
Researchers
- Principal investigator: Shuck, Sarah C. — Beckman Research Institute/city of Hope
- Study coordinator: Shuck, Sarah C.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.