Understanding how metabolic changes affect Hurthle cell carcinoma of the thyroid
Official title: Identifying metabolic dependencies in Hurthle cell carcinoma of the thyroid-Res 1
Funded at Ut Southwestern Medical Center · NIH-10894805 · Data updated 2026-11-12
This study is looking at how certain changes in the energy-making parts of cells help Hurthle cell carcinoma, a tough type of thyroid cancer, grow, and it hopes to find new treatment options for patients battling this cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project start | July 27, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $503,309 |
| NIH project number | 5R01CA276527-02 |
| Project ID | NIH-10894805 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients diagnosed with Hurthle cell carcinoma or other thyroid and kidney cancers exhibiting mitochondrial mutations.
✕Less likely to help
Patients with non-cancerous thyroid conditions or those without mitochondrial mutations may not benefit from this research.
What this research studies
This research investigates the metabolic adaptations that support the growth of Hurthle cell carcinoma, a type of aggressive thyroid cancer. It focuses on mutations in the mitochondrial DNA that may influence tumor metabolism and growth. The study employs various innovative methods, including monitoring carbon metabolism in surgical patients and testing new therapeutic options derived from patient models. By exploring these metabolic dependencies, the research aims to uncover potential treatment strategies for patients with this cancer.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for patients with Hurthle cell carcinoma and potentially other related cancers.
How similar studies have gone: Previous research has shown promising results in targeting metabolic pathways in cancer, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
-
Ut Southwestern Medical Center
Dallas, United States Active
Researchers
- Principal investigator: Mcfadden, David Glenn — Ut Southwestern Medical Center
- Study coordinator: Mcfadden, David Glenn
Related research
Other NIH-funded projects on the same topics.
-
Novel idea: Epstein-Barr virus and eye cancer in people living with HIV in Zimbabwe
A study explores whether Epstein-Barr virus could cause a type of eye cancer in people living with HIV in Zimbabwe.
-
Glutamine and macrophage behavior in liver cancer
A funded project at a medical university aims to understand how the liver’s immune cells interact with a specific type of liver cancer by looking at metabolism, especially glutamine and ammonia.
-
Understanding bladder cancer biology to find new biomarkers and therapies
A study at Tuskegee University will look at the molecules inside high-grade bladder cancer to discover new markers and potential treatment targets.
-
Oral cancer recurrence predictor using tumor microbes and gene activity
This NIH grant explores how bacteria and immune signals inside oral cancer tumors relate to whether the cancer comes back, with the aim of making a practical risk predictor for patients.
-
Understanding how bladder cancer starts in Veterans exposed to carcinogens and the role of PPAR-g in early bladder cancer
A research team is studying how bladder cancer begins and progresses in Veterans exposed to carcinogens, focusing on the PPAR-γ protein and early precancerous changes.
-
Adding PSMA PET/CT imaging to liver cancer care for veterans
This project tests a new PET imaging approach to help diagnose and guide treatment for liver cancer in veterans.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.