Understanding how metabolic changes affect Hurthle cell carcinoma of the thyroid
Identifying metabolic dependencies in Hurthle cell carcinoma of the thyroid-Res 1
This study is looking at how certain changes in the energy-making parts of cells help Hurthle cell carcinoma, a tough type of thyroid cancer, grow, and it hopes to find new treatment options for patients battling this cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10894805 on NIH RePORTER |
What this research studies
This research investigates the metabolic adaptations that support the growth of Hurthle cell carcinoma, a type of aggressive thyroid cancer. It focuses on mutations in the mitochondrial DNA that may influence tumor metabolism and growth. The study employs various innovative methods, including monitoring carbon metabolism in surgical patients and testing new therapeutic options derived from patient models. By exploring these metabolic dependencies, the research aims to uncover potential treatment strategies for patients with this cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients diagnosed with Hurthle cell carcinoma or other thyroid and kidney cancers exhibiting mitochondrial mutations.
Not a fit: Patients with non-cancerous thyroid conditions or those without mitochondrial mutations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for patients with Hurthle cell carcinoma and potentially other related cancers.
How similar studies have performed: Previous research has shown promising results in targeting metabolic pathways in cancer, suggesting that this approach could yield significant insights and advancements.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Mcfadden, David Glenn — Ut Southwestern Medical Center
- Study coordinator: Mcfadden, David Glenn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.