Understanding how metabolic changes affect calcium entry and cell behavior in lung blood vessels in pulmonary arterial hypertension.
Metabolic regulation of Ca2+ entry and endothelial-mesenchymal transition in pulmonary arterial hypertension
This study is looking at how changes in cell function, especially related to calcium and energy production, might cause problems in the blood vessels of the lungs for people with pulmonary arterial hypertension (PAH), with the hope of finding new ways to treat this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10852988 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind pulmonary arterial hypertension (PAH), a serious condition affecting blood vessels in the lungs. It focuses on how metabolic changes, particularly involving calcium signaling and mitochondrial function, contribute to the abnormal behavior of endothelial cells. By studying cells from both rats and humans, the research aims to uncover the links between increased calcium levels, mitochondrial dysfunction, and the transition of endothelial cells to a more aggressive state. This could lead to new therapeutic strategies targeting the underlying causes of PAH.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pulmonary arterial hypertension who may benefit from new therapeutic approaches targeting endothelial cell dysfunction.
Not a fit: Patients with pulmonary arterial hypertension who have already exhausted all treatment options or those with other unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that directly address the cellular dysfunctions causing pulmonary arterial hypertension.
How similar studies have performed: Previous research has shown promising results in understanding metabolic dysfunctions in similar conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Suresh, Karthik — Johns Hopkins University
- Study coordinator: Suresh, Karthik
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.