Understanding how metabolic changes affect blood vessel health
Official title: Metabolic interactions in the vascular wall: an integrated experimental and computational approach
Funded at Univ of Maryland, College Park · NIH-11063180 · Data updated 2026-11-12
This study is looking at how problems with blood sugar, cholesterol, and fats in the body can affect the blood vessels, and it aims to help people with metabolic syndrome find better treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Maryland, College Park NIH-funded |
| Lab location | 1 site (College Park, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $670,041 |
| NIH project number | 5R01HL165193-03 |
| Project ID | NIH-11063180 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over 21 years old who have been diagnosed with metabolic syndrome or related cardiovascular conditions.
✕Less likely to help
Patients without metabolic syndrome or those under 21 years old may not receive direct benefits from this research.
What this research studies
This research investigates the complex interactions between metabolic abnormalities and cardiovascular disease, particularly focusing on how these changes impact the cells lining blood vessels. By using a combination of experimental techniques and advanced computational modeling, the study aims to identify how elevated blood sugar, cholesterol, and triglycerides contribute to vascular dysfunction. Patients with metabolic syndrome, who often take multiple medications, may benefit from insights gained through this integrated approach, potentially leading to more effective treatment strategies. The research will utilize mass spectrometry data to analyze metabolic processes and develop new hypotheses for further studies.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with metabolic syndrome, reducing their cardiovascular disease risk.
How similar studies have gone: Other research has shown promise in using integrated approaches to study metabolic interactions, suggesting potential for success in this novel investigation.
Where this research is happening
-
Univ of Maryland, College Park
College Park, United States Active
Researchers
- Principal investigator: Morss Clyne, Alisa S — Univ of Maryland, College Park
- Study coordinator: Morss Clyne, Alisa S
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.