Understanding how messenger RNAs are organized for export from the cell nucleus
Official title: Identification of the core organizational principles within nuclear mRNAs
Funded at University of California at Davis · NIH-11068940 · Data updated 2026-11-12
This study looks at how certain proteins help move important messages in our cells, which could help us understand why some people have developmental delays or diseases related to RNA issues, and it uses yeast to learn more about these processes.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $75,052 |
| NIH project number | 1F32GM157894-01 |
| Project ID | NIH-11068940 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals with developmental delays or diseases linked to RNA binding protein dysfunction.
✕Less likely to help
Patients with conditions unrelated to RNA metabolism or developmental delays may not receive any benefit from this research.
What this research studies
This research investigates the role of RNA binding proteins in the packaging and export of messenger RNAs (mRNAs) from the nucleus of eukaryotic cells. By utilizing advanced techniques to isolate and study mRNA-protein complexes, the research aims to uncover how the structure of mRNAs affects their export efficiency. The study focuses on the model organism, budding yeast, to explore the mechanisms that may lead to developmental delays and diseases when these processes are disrupted. Patients may benefit from insights gained into the molecular causes of conditions linked to RNA metabolism.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of developmental delays and diseases associated with RNA metabolism, potentially informing new therapeutic strategies.
How similar studies have gone: While the specific approach of this research is innovative, similar studies have shown success in understanding RNA metabolism and its implications for disease.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Hatfield, Breanne — University of California at Davis
- Study coordinator: Hatfield, Breanne
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.