Understanding how messenger RNA splicing works and its regulation
Mechanisms of messenger RNA splicing and RNA processing regulation
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-10889947
This study is looking at how a special machine in our cells helps process genes, which is important for making proteins, and it aims to understand how this process can be affected by the surrounding DNA and how mistakes in it might lead to health issues.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10889947 on ClinicalTrials.gov |
What this research studies
This research investigates the complex process of messenger RNA splicing, which is essential for gene expression. It focuses on the spliceosome, a large molecular machine that assembles onto pre-messenger RNA and undergoes significant changes during splicing. The study aims to uncover how the assembly of this machinery is influenced by chromatin and how the retention of introns affects gene regulation and can lead to diseases. By utilizing advanced imaging techniques like cryo-electron microscopy, the research seeks to provide insights into the regulatory mechanisms of RNA processing.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic disorders or diseases linked to RNA processing abnormalities.
Not a fit: Patients with conditions unrelated to RNA splicing or gene regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases caused by misregulation of RNA splicing.
How similar studies have performed: Previous research has shown promising results in understanding RNA splicing mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JOHNSON, TRACY L — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: JOHNSON, TRACY L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers