Understanding how messenger RNA binding proteins regulate gene expression
Regulation of mRNA Fate
This study is looking at how certain proteins that bind to messenger RNA can change the way genes are expressed and proteins are made, using special cell lines from humans and chimpanzees to understand these processes better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Santa Cruz NIH-funded |
| Lab location | 1 site (Santa Cruz, United States) |
| Project ID | NIH-10842838 on NIH RePORTER |
What this research studies
This research investigates the roles of messenger RNA binding proteins (mRBPs) in controlling alternative splicing and mRNA translation. By utilizing genomics, molecular biology, and biochemistry, the team aims to uncover how specific RNA sequences influence gene expression and protein synthesis. The study will employ innovative cell lines that incorporate human and chimpanzee chromosomes to identify genetic variations that affect gene expression. This approach will help clarify the mechanisms by which alternative splicing impacts the stability and translation of mRNA.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic disorders influenced by mRNA processing, such as cystic fibrosis or certain cancers.
Not a fit: Patients with conditions unrelated to mRNA regulation or those not affected by alternative splicing may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into gene regulation that may improve treatments for various genetic disorders and cancers.
How similar studies have performed: Previous research has shown promising results in understanding mRNA regulation, indicating that this approach could yield valuable insights.
Where this research is happening
Santa Cruz, United States
- University of California Santa Cruz — Santa Cruz, United States (Active)
Researchers
- Principal investigator: Sanford, Jeremy Robert — University of California Santa Cruz
- Study coordinator: Sanford, Jeremy Robert
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.